Klotho cancer interplay
WebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large role in the regulation of phosphate, but this is only a small portion of the significance of Klotho. Klotho is currently making headlines because it's been linked to anti ... WebJan 2, 2024 · Increasing evidence strongly suggests that metabolic reprogramming is crucial for cancer stem-like cells to maintain unlimited self-renewal potential and hyper-adaptation to drastic changes in the tumor microenvironment [4,5].Cancer stem cells have a robust phenotype, encompassing several characteristics such as a slow cell cycle, the …
Klotho cancer interplay
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WebMay 12, 2024 · Fig. 1: Klotho decreases oxygen consumption rate (OCR) in breast cancer cells. a MCF-7 cells were seeded in at a density of 15,000 cells/well and after 24 h were treated with klotho (0.1... WebMar 23, 2012 · Quantitative real-time PCR analysis identified frequent elevation of KLB gene expression in HCC tumors relative to matched non-tumor tissue, with a more than two-fold increase correlating with development of multiple tumors in patients. KLB-silencing in Huh7 cells decreased cell proliferation and suppressed FGFR4 downstream signaling.
WebAbstract Klotho (KL) gene has been accepted as an "aging suppressor" gene that encodes a single transmembrane protein in human known as Klotho which is commonly expressed … WebApr 11, 2024 · Many cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medication. This is the case, for example, with alpelisib, a drug ...
WebMay 24, 2024 · This review article focuses on the effects of microRNAs on the performance of Klotho and how the interplay between Klotho and certain pathways like insulin-like … WebJul 5, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are …
WebJun 12, 2024 · The anti-aging factor, klotho has been identified as a tumor suppressor in various human cancers, including lung cancer. In vitro studies provided evidence that …
WebApr 12, 2024 · Transcription factors (e.g., Smad3 and NF-κB) downregulate Klotho and PGC-1α expression, whereas PGC-1α expression is promoted by histone crotonylation. A comprehensive understanding of these mediators might contribute to the establishment of novel therapeutic approaches towards CKD prevention and progression . The mechanism … technix rubber \\u0026 plastics ltdWebOct 19, 2024 · The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several aging-related diseases, such as Alzheimer’s disease, kidney injury, cancer, chronic obstructive pulmonary disease (COPD), vascular disease, muscular dystrophy and … spawn command instant tameWebMar 1, 2024 · BackgroundEnhanced inflammation and reduced Klotho are common features in chronic kidney disease (CKD). Inflammation induces DNA hypermethylation. This study assessed the performance of inflammatory marker C-C motif chemokine 5 (CCL5) in epigenetic regulation of Klotho expression.MethodsFifty CKD patients and 25 matched … technlogy radarWebMethods: We performed a mass spectrometry (MS) assay to screen candidate proteins complexed with Klotho derived from immunoprecipitation in human non-small cell lung cancer (NSCLC) cells, and ... technix netherlandsWebKlotho participates in mineral homeostasis via interplay with other calciophosphoregulatory hormones (parathyroid hormone, fibroblast growth factor-23, and 1,25- [OH]2 vitamin D3) in kidney, bone, intestine, and parathyroid gland. Klotho also may be involved in acute and chronic kidney disease development and progression. spawnconfig mtaWebJul 1, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are involved in pancreatic cancer development. We, therefore, undertook to study the expression and activity of klotho in pancreatic cancer. Experimental design: spawn commands minecraft modWebMar 12, 2024 · α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of multiple diseases and age-related phenotypes. Pre-clinical evidence suggests that boosting α-Klotho holds therapeutic potential. spawn companion