Hif bnip3

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August undefined, 2024

WebOverexpression of BNIP3 in Rat-1 fibroblasts and breast cancer cells (MCF7) induces apoptosis by binding to and inhibiting the antiapoptotic proteins Bcl-2 and Bcl-xL. 57 Hypoxia induced apoptosis mediated by … Web9 de abr. de 2024 · Nanomaterials are gaining increasing attention as innovative materials in medicine. Among nanomaterials, zinc oxide (ZnO) nanostructures are particularly appealing because of their opto-electrical, antimicrobial, and photochemical properties. Although ZnO is recognized as a safe material and the Zn ion (Zn2+) concentration is strictly regulated …

HIF-1介导的自噬在心脏疾病中的研究进展_参考网

Web15 de jun. de 2024 · Unlike HIF-1α and REDD1 (expressed transiently), Bnip3 was time-dependently induced by iron chelation, and high levels of Bnip3 were detectable after 24-h treatment with CPX or Dp44mT (Fig. S4A, B). Webbnip3的表达受到转录因子hif-1a的调控，在低氧诱导细胞自噬凋亡过程中起重要的作用。然而，唾液腺腺样囊性癌中BNIP3的表达、其调节的低氧诱导自噬通路及临床病理学行为 … how are refurbished phones

HIF-1α/BNIP3信号通路调节的低氧诱导自噬在唾液腺腺样 ...

WebNational Center for Biotechnology Information Web6 de out. de 2024 · HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. Web27 de dez. de 2024 · HIF-1 α exerts its antiapoptotic function through transcriptional activation of antiapoptotic proteins: Bcl-2, apoptosis inhibitor (IAP-2), and GLUT1. On the other hand, a functional pathway of HIF-1 α can activate proapoptotic proteins: p53, Bax, and BNIP3 [ 5 ]. how are regional variant patterns established

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects …

The Role of HIF in Immunity and Inflammation - ScienceDirect

Web1 de jan. de 2024 · In this study, we further observed that zinc chelators EDTA can significantly reduce the concentration of intracellular Zn 2+, reverse the inhibition of OS cell proliferation, migration and invasion, block HIF-1a upregulation and β-catenin downregulation (Supplementary Fig. S6; Fig. 8), which suggested that it is the Zn 2+ … Web1 de mai. de 2024 · However, the addition of exogenous disodium-fumarate (Fig EV4E) failed to rescue the levels of HIF-1α in the BNIP3-silenced cells. Together, these data … how many miles in 10000WebWhile hypoxia-inducible factor (HIF) is a major actor in the cell survival response to hypoxia, HIF also is associated with cell death. Several studies implicate the HIF-induced putative … how are regions of new mexico different

"Web1 de set. de 2001 · To additionally check the role of Hif-1α in BNIP3 induction, CHO KA13 and C4.5 cells were subjected to normoxia or hypoxia for 16 h before being analyzed … " - Hif bnip3

Hif bnip3

BNIP3L/NIX-mediated mitophagy: molecular mechanisms and

Web通过对这3个物种的 phd2 的功能进行探究发现: 3个物种的 phd2 在常氧情况下均可以降解3个物种的 hif-α(包括hif-1α和hif-2α) 蛋白, 而在低氧(o 2 浓度小于2%)情况下, phd2 则无法明显降解 hif-α 蛋白。在常氧下, 鲸类的 phd2 降解 hif-α 是依赖于识别鲸类的 hif-1α 上ltllap和 ... WebAnti-HIF-1 alpha antibody [EP1215Y] (ab51608) View more associated products. Overview. Product name. HIF1a + BNIP3 Hypoxia Response Human Flow Cytometry Kit. Detection method. ... BNIP3 readout. …

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WebResults: The expression levels of BNIP3, HIF-1α and marker genes of autophagy were upregulated in ARPE-19 cells in response to hypoxia. Importantly, hypoxia-induced … WebBackground: To explore the roles of HIF1α- and HIF2α-regulated BNIP3 in hypoxia-induced injury of neurons. Methods: The sera of neonates with hypoxic-ischemic encephalopathy …

Web31 de jan. de 2024 · BNIP3 mRNA and protein levels are enhanced due to a HRE that occurs in the proximal promoter for bnip3 that binds to the heterodimer of HIF-1, inducing BNIP3 expression [ 14 ]. Hypoxia-induced high-level transcription of bnip3 is mediated by E2F1 releasing from E2F4 and FoxO3 to enhance HIF-1α transcriptional function [ 15, …

Web1 de set. de 2024 · HIF-1α-BNIP3 signaling pathway contributes to mitophagosome formation in renal tubular cells in confocal assay. Representative immunofluorescence … Web21 de mar. de 2024 · BNIP3 (BCL2 Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include Hereditary Leiomyomatosis And Renal Cell …

WebIn contrast, adenovirus-mediated BNIP3 overexpression significantly reversed the decreased mitophagy, and prevented enhanced kidney damage in tubular HIF-1α …

Web17 de mai. de 2024 · BNIP3 depletion halted mitophagy and enforced a PHD2-mediated downregulation of HIF-1α and its glycolytic program both in vitro and in vivo. … how are refurbished iphonesWebAnti-HIF-1 alpha antibody [EP1215Y] (ab51608) View more associated products. Overview. Product name. HIF1a + BNIP3 Hypoxia Response Human Flow Cytometry Kit. Detection method. ... BNIP3 readout. HeLa … how many miles honda civic lastWeb13 de jul. de 2024 · Hypoxia-inducible factor-1 (HIF-1) dependent expressions of DRP1 and phosphorylated DRP1 and mitophagy-related protein BNIP3 were significantly upregulated in hypoxia-surviving HCC cells (Fig. 1e). how are regular iras taxedWeb2、n autophagy mediated by HIF-1/BNIP3 and missed abortion By:Yinfang Wang Supervisor:Enwu Yuan Clinical Laboratory Diagnostics The Third Affiliated Hospital of Zhengzhou University May2024 原创性声明原创性声明秉承郑州大学严谨的学风与优良的科学道德，本人郑重声明：所呈交的学位论文，是本人在导师的指导下，进行研究所取得 … how many miles high is the firmamentWeb13 de jun. de 2008 · Cell Death & Differentiation - Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Skip to main content. … how are regions determinedWeb6 de abr. de 2024 · HIF-1-dependent BNIP3 expression was proven to induce mitophagy in prolonged hypoxia . HIF-1 enhances the expression of BNIP3 and its closely related protein BNIP3L by directly binding to HREs on ... how many miles iditarod raceWeb缺氧诱导因子及相关靶基因与卒中的关系研究进展.pdf how many miles honda crv last