Chromosome substitution strains

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August undefined, 2024

WebSep 29, 2024 · Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due solely to … WebJun 29, 2016 · Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently requires the identification of the respective phenotypic trait of interest and is simply based on a significant difference between a consomic and host strain. However, statistical significance as …

(PDF) Chromosome Substitution Strains

WebChromosome substitution strains (CSSs) are a powerful complement to existing resources for studying multigenic traits. By partitioning the genome into a panel of … WebJAX® Mice substrains were used to generate panels of consomic (chromosome substitution) strains for use as gene mapping tools 21. The Complex Trait Consortium (www.complextrait.org) plans to use JAX® Mice substrains as progenitor strains for the generation of >500 recombinant inbred strains 22. c# type from string

Chromosome Substitution Strain - an overview

WebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, … WebNov 4, 2024 · Chromosome substitution strains C57BL/6J-Chr# A /J/NaJ (20, 23), hereafter referred to as CSS, for all chromosomes except Y and the mitochondrial genome, were purchased from the Jackson Laboratory (JAX, Bar Harbor, Maine) and imported to the University of Colorado Boulder. The JAX strain IDs for the CSS are continuous from … WebSep 8, 2012 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic … easily trusting synonym

Gene expression analysis of mouse chromosome substitution strains ...

Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome …

WebDec 1, 2003 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations ... WebChromosome substitution strains (CSS) were originally obtained as a gift from Dr. Joseph Nadeau (Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106). Each CSS is a homozygous inbred strain that is C57BL/6J with one chromosome pair from A/J. easily transfer photos from android to pcWebChromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic … easily understood crossword

"WebA chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substituted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for quantitative trait loci (QTLs) … " - Chromosome substitution strains

Chromosome substitution strains

WebJun 12, 2006 · An analysis of transcriptional variation in the liver using a panel of B.A chromosome substitution strains identified 4209 transcripts that are differentially expressed relative to the C57BL/6J background and 1010 transcripts that are differentially expressed between C57BL/6J and A/J strains. A subset of these strains (substituting … WebChromosome substitution strains (CSSs) are based on a different paradigm that deal with the signal-noise problem in a novel way ( 20 ). Each CSSs is an inbred strain that differs from the host strain by a single intact and homozygous chromosome on a defined and uniform genetic background.

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WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We … WebRecombinant inbred (RI) and chromosome substitution (CS) strain panels Many common inherited human diseases — such as diabetes, cardiovascular disease, obesity, …

WebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. WebChromosome Substitution Strains: A New Way to Study Genetically Complex Traits Article Full-text available Feb 2006 Annie E Hill-Baskin Eric S Lander Joseph H Nadeau Many biological traits and...

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WebFeb 1, 2006 · (3) Chromosome substitution strains (CSS) Chromosome substitution strains (CSS) are mice strains with one single chromosome replaced by the corresponding chromosome from a donor strain...

WebMay 23, 2024 · chromosome substitution The replacement of one or more chromosomes by others (totally or partially homologous) from another source (either a different strain of the same species or a related species that will permit hybridization) by a suitable crossing programme. A Dictionary of Zoology MICHAEL ALLABY easily trustpilotWebMar 28, 2024 · 5.3 Chromosome Substitution or Consomic Strains 5.3.1 Consomic Strains 5.4 Segregating Inbred Strains 5.5 Conplastic Strains 6. Outbreds and Closed Colonies 6.1 Outbreds 6.2 Closed Colonies 7. ES cell lines and iPS cell lines 8. References 1. Introduction Mice and rats used in the laboratory derive from a variety of sources. easily tired and sleepyWebGenetic resistance to diet-induced obesity in chromosome substitution strains of mice.pdf. 2011-11-03 ... easily torn skinWebSep 8, 2012 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations,... ctypegenWebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,... easily understood bible versionsWebJul 8, 2003 · A chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substi-tuted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for … c type folding tableWebSep 8, 2012 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations, and systems analysis. CSSs are made by replacing a single chromosome in a host strain with the corresponding chromosome from a donor … easily understood crossword solver